ABSTRACT
Background: The main purpose of this study is to evaluate the effects of varicocelectomy on serum testosterone levels and semen quality in infertile men who suffer from varicocele
Materials and Methods: This prospective study enrolled 115 subjects with clinical varicocele grades II and III and 240 fertile men as the control group. Total volume of testosterone serum level [ng/dl] and semen quality were com- pared before and after microscopic varicocelectomy. We normalized testosterone serum levels for age, grade, and testis size basis. SPSS 20 software was used to analyze the data. All results of continuous variables were reported as mean +/- SD. Statistical significance was set at a P<0.05
Results: The mean ages of individuals who participated in the treatment [32.2 +/- 5.23] and control [32.8 +/- 5.27] groups were similar. There were similar mean values for adjusted testosterone levels between the varicocele [567 +/- 222 ng/ml] and control [583 +/- 263 ng/ml] groups. In the varicocele group, the adjusted testosterone levels insig- nificantly increased to 594 +/- 243 ng/ml. Among semen parameters, only mean sperm concentration significantly increased after varicocelectomy
Conclusion: Despite increases in sperm concentration, adjusted testosterone levels did not significantly improve after varicocelectomy
ABSTRACT
To evaluate predictive factors of successful microdissection-testicular sperm extraction [MD-TESE] in patients with presumed Sertoli cell-only syndrome [SCOS]. In this retrospective analysis, 874 men with non-obstructive azoospermia [NOA], among whom 148 individuals with diagnosis of SCOS in prior biopsy, underwent MD-TESE at Department of Andrology, Royan Institute, Tehran, Iran. The predictive values of follicle stimulating hormone [FSH], luteinizing hormone [LH], and testosterone [T] levels, testicular volume, as well as male age for retrieving testicular sperm by MD-TESE were analyzed by multiple logistic regression analysis. Testicular sperm were successfully retrieved in 23.6% men with presumed SCOS. Using receiver operating characteristic [ROC] curve analysis, it was shown that sperm retrieval rate in the group of men with FSH values >15.25% was 28.9%. This was higher than the group of men with FSH